Generation and Assembly of Cell-laden Hydrogels on a Digital Microfluidic Platform
نویسندگان
چکیده
We demonstrate an integrated platform combining (1) digital microfluidic and (2) photo-patterning techniques to manipulate and fabricate cell-laden hydrogels for the tissue engineering application. Different hydrogels cured from individuallydriven polymer droplets provide three-dimensional (3D) microenvironments for in vitro cell culture. With the ability to actively drive the polymer droplets, assemble the hydrogels, and arrange the cells inside the hydrogel, this work provides an essential approach to tissue engineering, cell-cell interaction, stem cell differentiation studies on a highly programmable digital microfluidic device.
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تاریخ انتشار 2012